▎ 摘　　要

NOVELTY - A specific targeting radionuclide marker comprises graphene-based tumor cell nuclear targeting fluorescent nanoprobes, a linking reagent, and radionuclides, sequentially covalently linked. The graphene-based fluorescent nanoprobes and nuclear targeting are connected by amine bond. Radionuclides comprise radionuclide (r1) and radionuclide (r2). Radionuclide (r1) is iodine isotope. Radionuclide (r2) is lutetium isotope, technetium isotope, indium isotope, yttrium isotope, fluorine isotope, copper isotope, gallium isotope, samarium isotope, zirconium isotope, actinium isotope, and rhenium isotope. USE - Specific targeting marker is used for preparing tumor early diagnostic imaging agent and radiotherapeutic preparation (all claimed). ADVANTAGE - The specific targeting marker provides diagnostic imaging agent which enables tumor detection with reduced side effects of radionuclides on normal tissue. DETAILED DESCRIPTION - A specific targeting radionuclide marker comprises graphene-based tumor cell nuclear targeting fluorescent nanoprobes, a linking reagent, and radionuclides, sequentially covalently linked. The graphene-based fluorescent nanoprobes and nuclear targeting are connected by amine bond. Radionuclides comprise radionuclide (r1) and radionuclide (r2). Radionuclide (r1) is iodine isotope. Radionuclide (r2) is lutetium isotope (177Lu), technetium isotope (power(99m)Tc), indium isotope (111In), yttrium isotope (90Y), fluorine isotope (18F), copper isotope (64Cu, 67Cu), gallium isotope (67Ga, 68Ga), samarium isotope (153Sm), zirconium isotope (89Zr), actinium isotope (225Ac), and rhenium isotope (186Re, 188Re). An INDEPENDENT CLAIM is included for preparation of the specific targeting radionuclide marker, which involves mixing phosphate-buffered saline and a solution of the linking reagent and radionuclides, reacting in presence of an oxidant, and mixing obtained reaction solution with graphene-based tumor cell nuclear targeting fluorescent nanoprobes solution.