▎ 摘　　要

NOVELTY - Thermosensitive polymer@graphene oxide capsule medicine carrier is provided with silica ball as a template. The hollow cross-linked polymer capsules are prepared by reversible addition-fracture chain transfer radical polymerization, while the outer surface is coated with graphene oxide. USE - Thermosensitive polymer@graphene oxide capsule medicine carrier used for preparing cancer therapeutic medicine carrier (claimed). ADVANTAGE - Thermosensitive polymer@graphene oxide capsule medicine carrier is dissociated into a polymer chain small sheet, and is easily excreted, and reduces capsule drug carrier toxicity in the body. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for preparing thermosensitive polymer@graphene oxide capsule medicine carrier, which involves: (A) preparing phenyl-trimethoxysilyltris trithiocarbonate by taking 1.6 g of sodium methoxide and 4.86 g of anhydrous methanol and pouring into a three-necked flask; (B) taking solution of 6.2 g of 3-mercaptopropyltrimethoxysilane in methanol under a nitrogen atmosphere and adding dropwise; (C) carrying out the reaction at room temperature for 0.5 h; (D) adding 3.05 g of CS2 dropwise and reacting at room temperature for 5 h: (E) adding 5.24 g of benzyl bromide to the solution and stirring for 12 h under nitrogen; (F) removing methanol by steaming and then extracting with dichloromethane, filtering; (G) distilling off dichloromethane is under reduced pressure, and then drying in a vacuum oven to obtain phenyl-trimethoxysilyltris trithiocarbonate, where volume of the methanol solution is 50 mL; (H) preparing phenyl-trimethoxysilyltris trithiocarbonate grafted SiO2 particles by dispersing 1-2 g of SiO2 uniformly in dry toluene;: (I) adding phenyl-trimethoxysilyltris trithiocarbonate to the solution, and refluxding for 48 h; (J) ishing reaction product with dry toluene for 3-5 times, centrifuging at 8000 rpm for 5 min and then drying in an oven at 50-70 degrees C for 3-5 hours to prepare phenyl-trimethoxysilyltris trithiocarbonate grafted SiO2 particles; (K) preparing silica / copolymer particles by adding 0.1-0.5 g of phenyl-trimethoxysilyltris trithiocarbonate-grafted SiO2 particles, 0.2-1.0 g of N-isopropylacrylamide, 20-100 mg of acrylamide, 5-50 mg of cross-linking agent N, N'-bis (acryloyl) cystamine and 1-10 mg of azobisisobutyronitrile to 50-150 mL of tetrahydrofuran; (L) degassing at -65 degrees C for 12-24 h, then centrifuging at 10,000 rpm for 10 min and resulting solid product is dried in a vacuum oven for 6-12 hours to obtain silica / copolymer particles; (M) preparing hollow temperature sensitive polymer capsules by adding 0.2-1.0 g of silica / copolymer particles and dispersing in 5-20 mL of deionized water, and then adding 0.2-1 mL of hydrofluoric acid solution and reacting at room temperature for 4 h; (N) adding reaction solution to dialyzed bags with a molecular weight of 8,000 for 2 to 3 days and freeze-drying for 12-24 h to prepare hollow thermosensitive polymer capsules; (O) preparing graphene solution by taking 1-10g of graphite to 100-1000mL concentrated sulfuric acid, stirring for 24h; (P) adding 5-25g potassium permanganate to the solution and placing in ice bath for 2-24h, adding 100-1000mL deionized water and stirring; (Q) adding 5-15mL of hydrogen peroxide, washing with multiple centrifugation to obtain a solution, freeze-drying to obtain graphene powder and preparing 0.05-2mg / mL graphene solution; (R) preparing thermosensitive polymer @ oxide graphene capsules medicine carrier by adding 1-4 mg of doxorubicin hydrochloride and 2-10 mg of the hollow temperature sensitive polymer capsule and dispersing in 2-10 mL of deionized water; (S) stirring mixture at room temperature for 12 hours; (T) removing supernatant of doxorubicin hydrochloride by centrifugation, and the precipitate is redispersed in deionized water to obtain a polymer capsule solution of doxorubicin hydrochloride; and (U) adding 0.05- 2mg / mL graphene solution dropwise to the polymer capsule solution filled with doxorubicin hydrochloride and stirring at room temperature for 2 hours to obtain a thermo-sensitive polymer @ enriched graphene capsule drug carrier.