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  • 专利标题:   Biosensor used for detecting analyte, comprises sensor base having insulating substrate and working electrodes, reduced graphene, spacer covalently bonded to reduced graphene, and antigen-binding fragment covalently bound to spacer.
  • 专利号:   DE102016108979-A1, WO2017194746-A1, EP3455629-A1, US2019187090-A1
  • 发明人:   GRABBERT N, MEYER V, LANG K, FIEDLER M
  • 专利权人:   FRAUNHOFER GES FOERDERUNG ANGEWANDTEN EV, FRAUNHOFER GES FOERDERUNG ANGEWANDTEN EV, FRAUNHOFER GES FOERDERUNG ANGEWANDTEN EV
  • 国际专利分类:   G01N027/327, G01N033/50, G01N033/543, G01N027/00, G01N027/30, G01N027/414
  • 专利详细信息:   DE102016108979-A1 16 Nov 2017 G01N-033/50 201779 Pages: 25 German
  • 申请详细信息:   DE102016108979-A1 DE10108979 13 May 2016
  • 优先权号:   DE10108979

▎ 摘　　要

NOVELTY - Biosensor comprises (a) a sensor base having an insulating substrate and at least one electrically conductive working electrode located on the substrate, where the working electrode is formed from separately controllable interdigital electrodes, (b) reduced graphene (rGO) applied to at least one of the working electrodes, (c) a spacer covalently bonded to the rGO, (d) an antigen-binding (Fab) fragment covalently bound to the spacer. USE - The biosensor is useful for detecting analyte (claimed) molecule e.g. an antigen or biomarker. ADVANTAGE - The biosensor is biocompatible and reliable, and is produced in a simple, rapid and cost-effective manner and detects analyte in an accurate manner with improved detection sensitivity within a short period of time, and has enhanced reaction kinetics, prevents unwanted noises due to bacterial growth and is suitable for mass production. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a method for producing the biosensor; and (2) method for detecting an analyte.