国家/地区 美国（10）
IPC部 G（10） A（6） C（5）
B（2） H（2）
IPC大类 G01（10） A61（6） C01（4）
G16（2） H01（2）
IPC小类 G01N（10） A61B（6） C01B（4）
G16H（2） H01L（2）
IPC G01N027/22（10） A61B005/08（5） G01N027/12（5）
C01B032/194（4） G01N033/00（4） G01N033/497（4）
G01N001/22（2） G01N027/414（2） G16H050/20（2）
发明人 NELSON J T（8） BUHLMANN P P J（7） ZHEN X（7）
KOESTER S J（6） SHERWOOD G J（5） KOESTER S（2）
SU Q（2）
公开年 2021（4） 2019（2） 2020（2） 2022（2）
申请年 2019（4）  2020（2）  2021（2）  2022（2） 
专利权人 BOSTON SCI SCIMED INC（10）

System for analyzing fluid sample, has capacitance sensor that measures capacitance of discrete binding detectors resulting from applied voltage and hysteresis effects related to capacitance versus voltage values obtained from graphene varactors.

KOESTER S, SU Q, BUHLMANN P P J, ZHEN X, NELSON J T, SHERWOOD G J

Medical device used for detecting aldehyde and ketone-bearing analytes, comprises graphene varactor comprising graphene layer, and self-assembled monolayer provided on outer surface of graphene layer through electrostatic interactions.

TROUDT B K, BUHLMANN P P J, KOESTER S J, ZHEN X, KOESTER S

Medical device comprises graphene varactor comprising graphene layer, and non-covalent modification layer disposed on outer surface of graphene layer.

BUHLMANN P P J, KOESTER S J, NELSON J T, ZHEN X

Detecting disease state in a subject comprises e.g. obtaining liquid biological sample from the subject and placing it into a container, contacting the liquid biological sample with a first chemical sensor element, and sensing.

ROGNRUD C B, KOYA V, JUDISCH A, TASSONI A F, SHERWOOD G J, FROST K L, NELSON J T

Producing graphene sensor element used for analyzing gas sample, by forming graphene layer on growth substrate, applying fluoropolymer coating layer, removing substrate, transferring onto substrate, and removing fluoropolymer coating layer.

SHERWOOD G J, NELSON J T, SU Q, BUHLMANN P P J, ZHEN X, KOESTER S J

Medical device used in detection of analyte e.g. volatile organic compound in gaseous sample, comprises graphene varactor comprising graphene layer, and self-assembled monolayer containing calixarene, substituted calixarene and/or pyrene.

ZHEN X, BUHLMANN P P J, KOESTER S J

Method for detecting health condition of subject, involves contacting gas from headspace with chemical sensor element comprising discrete graphene varactors and sensing and storing capacitance of graphene varactors to obtain sample data set.

SHERWOOD G J, NELSON J T

Method for detecting brain condition in subject, involves sensing and storing capacitance of discrete graphene varactors to obtain sample data set, and classifying sample data set into pre-established brain condition classifications.

PETERSON G K, NELSON J T, SHERWOOD G J

Medical device for detecting volatile organic compounds in gaseous sample from patient, comprises graphene varactor comprising graphene layer, and self-assembled monolayer comprising substituted porphyrins or substituted metalloporphyrins.

ZHEN X, BUHLMANN P P J, KOESTER S J, NELSON J T

Medical device used for detecting analytes in gaseous sample, such as breath of patient, to identify disease state, e.g. cancer, comprises graphene varactor comprising graphene layer and self-assembled monolayer formed on graphene layer.

ZHEN X V, BUHLMANN P P J, KOESTER S J, ZHANG Y, NELSON J T, ZHEN X