国家/地区 世界知识产权组织（5） 中国（3） 美国（2）
IPC部 C（10）
IPC大类 C12（10） G01（7） A61（3）
B01（2） B03（2）
IPC小类 C12Q（10）
IPC C12Q001/6886（10）
发明人 GARDNER L（2） HADJIDEMETRIOU M（2） HE M（2）
KOSTARELOS K（2）
公开年 2021（6） 2022（4）
申请年 2021（10）
专利权人 UNIV KANSAS（2） UNIV KANSAS .（2） UNIV MANCHES.（2）

Composition used to isolate extracellular vesicle, comprises many magnetic particles, each magnetic particle comprising core particle and targeting moiety extending from the core particle via photocleavable linker.

HE M

Identifying cell free nucleic acid in bio-fluid for diagnosing or monitoring or detecting disease state in subject, such as cancer disease, involves contacting nanoparticles with bio-fluid of subject, isolating nanoparticles, and analyzing.

HADJIDEMETRIOU M, KOSTARELOS K, GARDNER L

Identifying biomarkers from distinct biomolecule classes in biofluid by contacting nanoparticles with biofluid to allow biomolecule corona to form on surface of nanoparticles, isolating nanoparticles and surface-bound biomolecule corona, and analyzing biomolecule corona to identify biomarkers.

HADJIDEMETRIOU M, KOSTARELOS K, GARDNER L, PAPAFILIPPOU L

Performing clinical trial for cancer therapy regimen for evaluating hospice patient, involves administering first cancer therapy regimen to first group of patients having cancer.

TAUB F

Vascular access port system for detecting circulating ctDNA in situ in subject, comprises implantable indwelling device for detection of circulating ctDNA and DNA detector comprising DNA probes positioned at catheter and reservoir.

KHAN A

Biosensor useful for detecting miR-205 in non-disease diagnosis by qualitative detection or quantitative detection, comprises miR-205, hairpin nucleic acid probe HCR1, hairpin nucleic acid probe HCR2, graphene oxide and buffer.

JIN J, CAI Y, QIN L, YIN S, YANG D, YANG Z

Device for detection and prognosis of chronic disease, comprises a strip, biosensor, processor, and communication unit, where the strip receives test sample selected from saliva, urine or sweat and propagates sample to flow through strip.

PERUMAL Y, KODUVAYUR GANESHAN S, MADABHOOSHI PADMANABAN S

Use of methylated DNA as marker for preparing kit or DNA sensor for early cancer diagnosis and tumor treatment targeted medicine.

LIU F, LI C, LIU H, DENG J, FANG L, ZHU C, WANG L, HUANG H, LI Y, ZHU Q, ZHENG J

Capturing and photoreleasing extracellular vesicles from test sample suspected of containing target extracellular vesicles involves contacting test sample with multiple immunomagnetic particles in test container.

HE M

Nanoprobe useful for preparing miRNAs products for detecting circulating tumor cells, comprises light-absorbing nanomaterials, polyethylene glycol, circulating tumor cell targets and fluorescent group-modified miRNAs single-stranded probes.

YANG M, CHEN Y, OUOUDENGGERILE, CHEN J