国家/地区 中国（36）
IPC部 C（36）
IPC大类 C12（36） G01（18） B01（7）
C01（3） A61（2） B82（2）
IPC小类 C12Q（36）
IPC C12Q001/6825（8） C12M001/34（7） C12Q001/02（5）
C12Q001/6844（5） B01L003/00（4） C12Q001/00（4）
C12Q001/689（4） G01N021/64（4） C12M001/00（3）
C12N015/11（3） C12Q001/682（3） C12Q001/6886（3）
C12Q001/70（3） G01N027/327（3） G01N027/414（3）
发明人 ZHANG X（5） LI H（4） FU W（3）
JING Q（3） LI J（3） QIN Y（3）
WANG Q（3） WU G（3） YANG D（3）
ZHANG Y（3） CHEN J（2） CHEN Y（2）
DING X（2） HUANG K（2） JIN J（2）
公开年 2021（27） 2022（9）
申请年 2021（36）
专利权人 UNIV TSINGHU.（3） UNIV CHINA A.（2） UNIV GUILIN .（2） UNIV JIANGNA.（2）
UNIV JIANGSU（2） UNIV SHANGHA.（2）

Graphene core particle useful in graphene biosensor and detecting activity of biomarker in biological sample, comprises pristine graphene nanosheets having pristine graphene nanosheet surface and coating layer covering the nanosheet surface.

DEMPSEY P W, HANTULA S, APARICIO C S, BOSSMANN S H, SORENSEN C M, COVARRUBIASZAMBRANO O, COVARRUBIAS J

Preparing gold nanocluster-polypeptide sensor for detecting chymotrypsin, involves preparing amino-functionalized graphene oxide using graphene oxide nanomaterials, and adding carbodiimide and N-hydroxysuccinimide separately to methyl-1-butyne solution.

LIU C, DENG Y, GAO L

Double-labeled graphene field effect transistor, where double-labeled graphene field effect transistor is modified with double-stranded specific nuclease and DNA probe,and DNA probes laid around DSN, and DNA probes located within spatial hydrolysis range of DSN.

ZHANG X, QIN Y, JING Q, WANG Q, FU W

Functionalized graphene field-effect transistor useful for detecting miRNA by using the functionalized GFET, comprises substrate, functionalized single-layer graphene, source/drain and reaction pool, where the functionalized GFET is covalently modified with DNA probe.

ZHANG X, QIN Y, JING Q, WANG Q, FU W

Hypoxanthine/aminopterin/thymidine (HAT) semi-solid screening culture medium useful for screening monoclonal antibody and culturing hybridoma cell culture, comprises biological protein hydrolyzate, carrier film, fetal calf serum and polyethylene glycol.

YAN G, WU G, LIU L

Detecting nucleic acid, e.g. SARS-CoV-2N gene, SARS-CoV-2E gene, HPV-16, HPV-18, involves using field effect transistors to amplify detection signal of Cas13a/Cas12a trans-cleavage in solution.

ZHANG X, WANG Q, JING Q, QIN Y, FU W

Simulating effect of toxins on neural stem cells through blood-brain barrier for use in study of simulating early developmental abnormalities of nervous system, involves observing physiological activity of neural stem cell.

GUAN M, CHANG H, CHEN F, TANG D, ZHANG Y, MU Y

New antisense nucleic acid molecule useful for screening novel Coronavirus antisense nucleic acids and preparing antisense drug for preventing and/or treating novel Coronavirus infection, comprises specific base pair sequences.

JIN J, SHEN Y, YANG D, YANG Z

Preparing upconversion fluorescent recognition probe used in detection of pathogenic bacteria in food, comprises connecting UCNPs-COOH with the amino functionalized DNA nanoprobes through EDC/NHS amide condensation reaction.

LI H, ZHANG Y, XU Y, XU J, CHEN Q, LIU R

Photoresponsive gel microsphere useful for detecting nucleic acid, preferably Proteus mirabilis nucleic acid is prepared by synthesizing ferrosoferric oxide-graphene oxide-silicon dioxide complex material, mixing with microdroplet solution, PCR reagent and sample and cutting into microdroplets.

WANG Y, YU J, ZHAO Y, ZHANG L, YE F