国家/地区 中国（10）
IPC部 B（10）
IPC大类 C12（10）
IPC小类 C12Q（10） G01N（9） B82Y（8）
C01B（4） C12M（3） B01L（2）
C25F（2）
IPC C12Q001/68（10）
发明人 GOLOVCHENKO J（2） GOLOVCHENKO J A（2）
公开年 2013（2） 2014（2） 2017（2）
申请年 2012（2）  2014（2） 
专利权人 HARVARD COLL.（2）

Detecting disease state in a subject comprises e.g. obtaining liquid biological sample from the subject and placing it into a container, contacting the liquid biological sample with a first chemical sensor element, and sensing.

ROGNRUD C B, KOYA V, JUDISCH A, TASSONI A F, SHERWOOD G J, FROST K L, NELSON J T

Producing sequencing unit useful for sequencing biochemical material, comprises creating sequencing pore for sequencing biochemical material in precursor layer by thermal lithography and converting pre-structured layer to graphene layer.

LAERMER F

Gene sequencing chip of gene sequencing device, has first electrode and second electrode which are configured to detect resistance of graphene oxide layer.

PANG F, CHE C, XUE H, SHAO X, CAI P

Nucleic acid detection device for detecting or discriminating nucleic acid having one or more mismatches, comprises graphene chip, double-stranded nucleic acid probe, and microcontroller board that comprises digital meter.

GLINSKII G V, HWANG M T, LAL R, LANDON P B, LEE J, MECKES B, MO A, RAMACHANDRAN S, LI Z

Method for forming nano-gaps in graphene used in e.g. electronic device, involves applying voltage across third region of single layer graphene such that nano-gap extending across the entire width of single layer graphene is formed.

BRIGGS G A D, MOL J A

Formation of modified graphene surface used for forming graphene layer for device e.g. nanoelectromechanical systems, involves providing defect-free graphene monolayer, and providing molecules comprising binding group in solvent.

SCHNEIDER G F, DEKKER C, DECKER C

Method for forming nanopore in graphene membrane in liquid environment, involves applying nanopore diameter tuning voltage pulse between membrane surfaces if electrical conductance is greater than prespecified electrical conductance.

GOLOVCHENKO J A, LU B, KUAN A T, GOLOVCHENKO J, KUAN A

Electrically differentiating/identifying bases/biomolecules in nanopore, by filling reservoir and nanopore formed through membrane including e.g. graphene layer with ionic buffer, where layer is wired to metal pads to form transistor.

PENG H, STOLOVITZKY G A, ZHU W, STOROVITZKI G A

Etching graphene nanostructure, by providing piece of highly oriented pyrolytic graphite, analyzing first window, second window, and third window, and applying voltage gradient.

DARLING M J

Graphene nanopore sensor useful for evaluating a polymer molecule, comprises a substantially bare, single-layer graphene membrane, a connection, and an electrical circuit.

SLAVEN G, BRANTON D, GOLOVCHENKO J A, GOLOVCHENKO J, GARAJ S