国家/地区 中国（11） 韩国（9） 美国（3） 欧洲专利局（EPO）（2） 世界知识产权组织（2）
IPC部 C（22）
IPC大类 C12（22）
IPC小类 C12Q（22） G01N（9） C01B（8）
C12N（6） C07K（3） C12M（3）
C07H（2）
IPC C12Q001/68（22）
发明人 HWANG D W（3） LEE D S（3） CHEN Q（2）
DENG T（2） HOU J（2） LIU Y（2）
NIU X（2） SUN W（2） YAN L（2）
公开年 2016（9） 2017（9） 2018（4）
申请年 2016（22）
专利权人 UNIV SEOUL N.（3） UNIV BEIJING.（2） UNIV CHUNG A.（2） UNIV HAINAN .（2）
UNIV KYUNGHE.（2）

Composition useful for detecting nucleic acid in exosome, comprises graphene, and probe containing fluorescent substance.

HWANG D W, LEE D S

Nanographene biosensor used in kit for detecting intracellular nucleic acid, comprises graphene containing hyaluronic acid and cell permeable peptide, and probe comprising fluorescent substance.

HWANG D W, LEE D S

Nanographene-sensor or diagnostic kit for detecting nucleic acid in a nuclear nucleus, for diagnosing neurodegenerative disease, comprises graphene containing a nuclear transition signal, and a probe containing a fluorescent substance.

HWANG D W, LEE D S

Detecting target nucleic acids by mixing single-stranded template with graphene or graphene oxide, adding e.g. cleavage enzyme, performing exponential isothermal amplification reaction, and confirming presence of nucleic acid.

JANG H, PARK H G, PARK J H

Preparing graphene oxide modified magnetic bead involves sulfonating porous polystyrene-di-vinyl benzene beads to obtain sulfonated beads, which are adsorb and selected from ferrous salts, ferric salts or mixtures, and magnetizing.

JUN B H, KIM D E, BAEK A R, XUAN H P, KIM T H

Graphene/silicon biosensor used in DNA detecting apparatus, comprise multiple silicon nanostructure aligned and bonded to substrate and coated with functional material including 3-aminopropyltriethoxysilane or glutaraldehyde.

SUK H C, JUNG K K

Electro-responsive multilayer nanofilms useful in DNA nanoswitch and other DNA nanodevices, comprise positively charged polymer layer, DNA layer, graphene layer and conductive polymer layer.

HONG J K, JEONG H J

Nucleic acid detection device for detecting or discriminating nucleic acid having one or more mismatches, comprises graphene chip, double-stranded nucleic acid probe, and microcontroller board that comprises digital meter.

GLINSKII G V, HWANG M T, LAL R, LANDON P B, LEE J, MECKES B, MO A, RAMACHANDRAN S, LI Z

Detecting sulfonated graphene useful for distinguishing between single base mismatched DNA and target DNA strand by adding e.g. target DNA to trisaminomethane-hydrochloric acid buffer, reacting and measuring e.g. fluorescence intensity.

CHEN W, WANG Y, DENG H, PENG H, LIN X

Nucleic acid detection complex useful for diagnosing hospital clinical disease and health conditions, comprises nucleic acid, gold nanoparticles and graphene oxide.

ZHANG Y, XUE B, CHANG Y, TU L, LIU X, KONG X